The Northern Sweden MONICA Study
Monica studien i norra Sverige
Health and Performance
|Relevance for this Topic||
Mats Eliasson and Stefan Söderberg / Department of Public health and Clinical medicine
901 87 Umeå
Email: Stefan.soderberg(at)medicin.umu.se; Mats.elisasson(at)medicin.umu.se
As evident the MONICA databases are extensively used by a large number of researchers locally, nationally and internationally. External users of the databases are invited for collaborative work. Throughout the existence of MONICA, very few proposals for usage of MONICA data have been turned down, if so always for quality reasons. We have had contacts with SND in order to plan a registration of MONICA with the SND initiative.
MONICA data from previous risk factor surveys are also available in a condensed form on our website. Two booklets containing key data, catering to the general population and politicians has been published and numerous meeting with media, patient’s consumer organisations, politicians and professional organisations have been performed where data pertinent to public health have been presented and discussed.
Conditions of access
Ethical considerations; Nominal costs and institutional agreement. Application form on website (Swedish) as well as formal contract.
To be discussed with principal investigator.
SPSS and excel (bio samples).
Dataset and variables in Swedish. General information in English.
The Northern Sweden MONICA Study started with the WHO MONICA Study in 1985. The purpose was to monitor trends in mortality and morbidity in cardiovascular disease and relate them to trends in risk factors. Since 1985 21,000 strictly validated stroke events and 18,000 myocardial infarctions have been included in two registers. During the same period, six population based surveys have been taking place, the latest in 2009.
Ever since the start of the WHO MONICA Projects, strict and uniform standards have been used for sampling and examinations and database procedures. Biological measurements have undergone continuous quality assurance programmes. Questionnaires are kept consistent throughout the surveys with similar categorisation and definitions, i.e. level of education and presence of hypertension. We are continuing the regular population surveys with 5-year intervals, the seventh survey is to take place in 2014. The MI registry will be merged with the stroke register thus giving an opportunity to study the total burden of cardiovascular disease within a single database. The MONICA cohort based on six cross-sectional population-based surveys provides a unique foundation for describing trends of socio-economic and biochemical risk factors in the population.
There are 8 datasets with the following characteristics:
The Northern Sweden MONICA Study 1986
1625 cases. 81% response frequency.
1985 (Clinical examination)
1985 (Self-completed questionnaire: Paper/pencil)
1985 (Extracts from registers)
A randomised sample of 2000 persons in ages 25-64 were invited to participate in the 1986 study.
The Northern Sweden MONICA Study 1990
1583 cases. 79% response frequency.
1990 (Clinical examination)
1990 (Self-completed questionnaire: Paper/pencil)
1990 (Extracts from registers)
A randomised sample of 2000 persons in ages 25-64 were invited to participate in the 1990 study.
The Northern Sweden MONICA Study 1994
1921 cases. 77% response frequency.
1994 (Clinical examination)
1994 (Self-completed questionnaire: Paper/pencil)
1994 (Extracts from registers)
A randomised sample of 2500 persons in ages 25-74 were invited to participate in the 1994 study.
The Northern Sweden MONICA Study 1999
1823 cases. 73 response frequency.
1999 (Clinical examination)
1999 (Self-completed questionnaire: Paper/pencil)
1999 (Extracts from registers)
A randomised sample of 2500 persons in ages 25-74 were invited to participate in the 1999 study.
The Northern Sweden MONICA Study 2004
1905 cases. 76% response frequency.
2004 (Clinical examination)
2004 (Self-completed questionnaire: Paper/pencil)
2004 (Extracts from registers)
A randomised sample of 2500 persons in ages 25-74 were invited to participate in the 1986 study.
The Northern Sweden MONICA Study 2009
1729 cases. 69% response frequency.
2009 (Clinical examination)
2009 (Self-completed questionnaire: Paper/pencil)
2009 (Extracts from registers)
A randomised sample of 2500 persons in ages 25-74 were invited to participate in the 2009 study.
The MONICA Myocardial Infarction Registry
Everyone who had a verified myocardial infarction in Norrbotten and Västerbotten in 1985. In 1985-1999 25-64 years-old were included, after that 25-74 years-old.
The MONICA Stroke Registry
People aged 25-74 years residing in Norrbotten or Västerbotten Counties who suffered a stroke has since 1985 been registered in the stroke registry.
Norrbotten and Västerbotten Counties/north Sweden
Individuals aged 25 – 74 years of age
Norrbotten and Västerbotten
The Northern Sweden MONICA Study is unique among Swedish registers in combining consistency over time (more than 25 years), broadness in data collection (comprehensive questionnaire data, health examinations, blood sampling) and coverage of cardiovascular determinants as well as end-points. As the MONICA cohorts are aging, a large share of the participants are now entering ages when they are prone to be affected by cardiovascular disease and other severe disorders of the elderly. The value of the project is therefore rapidly increasing. One of the strong features of the MONICA Study is its stability over time. Some of the applicants and collaborators have been involved in the project since the late eighties. The Västerbotten and Norrbotten county councils are formally responsible for incidence and population survey registers, and have provided partial financial support since the start of the project. It is foreseen that the basic structure of the MONICA population surveys and cardiovascular event monitoring will be unchanged.
The main scientific aim is to describe trends and determinants in cardiovascular disease and diabetes in the northern Sweden population. Additional aims of the database with the scientific network linked to it are to provide data for health planning identify etiologic factors of cardiovascular disease and diabetes, characterize the interplay between determinants, and to describe level, time trends, and determinants of exposure to certain environmental pollutants and compare these to other regions.
• Alssema, M., Vistisen, D., Heymans, M. W., et al. “The Evaluation of Screening and Early Detection Strategies for Type 2 Diabetes and Impaired Glucose Tolerance (DETECT-2) update of the Finnish diabetes risk score for prediction of incident type 2 diabetes.” Diabetologia 54(5) (2011): 1004-1012.
• Eliasson, M., Jansson, J.H., Lundblad, D., & Näslund, U. “The disparity between long-term survival in patients with and without diabetes following a first myocardial infarction did not change between 1989 and 2006: an analysis of 6,776 patients in the Northern Sweden MONICA Study.” Diabetologia 54 (10) (2011): 2538-43.
• Eriksson, M., Holmgren, L., Janlert, U., et al. “Large improvements in major cardiovascular risk factors in the population of northern Sweden: the MONICA study 1986-2009.” J Intern Med. 269 (2) (2011): 219-231.
• Isaksson, R., Jansson, J., Lundblad, D., et al. “Better long-term survival in young and middle-aged women than in men after a first myocardial infarction between 1985 and 2006. An analysis of 8360 patients in the Northern Sweden MONICA Study.” BMC Cardiovasc Disord 11(1) (2011). DOI: 10.1186/1471-2261-11-1.
• Isaksson, R.M., Holmgren, L., Lundblad, D., Brulin, C., & Eliasson, M. “Time trends in symptoms and prehospital delay time in women vs. men with myocardial infarction over a 15-year period. The Northern Sweden MONICA Study.” Eur J Cardiovasc Nurs. 7( 2) (2008):152-8.
• Janunger, T., Nilsson-Ardnor, S., Wiklund, P.G., et al. ”A novel stroke locus identified in a northern Sweden pedigree: linkage to chromosome 9q31-33.” Neurology 73 (21) (2009):1767-73.
• Karvanen, J., Silander, K., Kee, F., et al. “The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.” Genet Epidemiol. 33 (3) (2009): 237-46.
• Lilja, M., Eliasson, M., Stegmayr, B., Olsson, T., & Soderberg, S. “Trends in obesity and its distribution: data from the Northern Sweden MONICA Survey, 1986-2004.” Obesity (Silver Spring) 16 (5) (2008): 1120-8.
• Lilja, M., Rolandsson, O., Shaw, J. E., et al. “Higher leptin levels in Asian Indians than Creoles and Europids: a potential explanation for increased metabolic risk.” Int J Obes (Lond) 34 (5) (2010): 878-885.
• Lundblad, D., Holmgren, L., Jansson, J. H., Naslund, U., & Eliasson, M. “Gender differences in trends of acute myocardial infarction events: the Northern Sweden MONICA study 1985 - 2004.” BMC Cardiovasc Disord. 8 (17) (2008).
• Norlund, S., Reuterwall, C., Hoog, J., et al. “Burnout, working conditions and gender--results from the northern Sweden MONICA Study.” BMC Public Health 10 (326) (2010).
• Van Guelpen, B., Hultdin, J., Johansson, I., et al. “Plasma folate and total homocysteine levels are associated with the risk of myocardial infarction, independently of each other and of renal function.” J Intern Med. 266 (2) (2009): 182-95.
• Warensjo, E., Jansson, J.H., Cederholm, T., et al. “Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective, matched case-control study.” Am J Clin Nutr. 92 (1) (2010):194-202.
If you publish something on this study, please contact snd(at)snd.gu.se with the citation.
See above. The strong MONICA network, involving 13 professors and more than 10 other senior researchers in northern Sweden ensures collaboration in a vast national and international network and that the continued activities of the project are not dependent on the commitment of single individuals. The seven PhD students presently using MONICA data will guarantee the long time survival of the project.
The participation rates have been 69-81%. Subjects donated samples to the Northern Sweden Biobank. After 25 years since the start of the study, participants are starting to suffer from stroke, infarctions and diabetes in a rapidly increasing rate. We have successfully matched the event registers with population survey data, thereby creating a cost-effective prospective study design for MI, stroke and diabetes. Data from the three data bases has been used in more than 85 original studies and 14 dissertations since 2007. Increasingly other fields have been explored such as infectious diseases, nutrition and environmental toxins.
- The information about this dataset was compiled by the author:
- Kenneth Abrahamsson
- (see Partners)